Motrin (ibuprofen) is a nonsteroidal anti-inflammatory drug indicated for relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis, for relief of mild to moderate pain, and for treatment of primary dysmenorrhea. The best baby shower gift was a small plastic bin with infant Tylenol, infant Motrin, diaper rash cream, gas drops, saline nose drops, bulb syringe etc. Can viral infections cause bruising, a rash and itchy skin? I've improved. But i'm wondering what the cause is. Also can ibuprofen make you bruise? I've improved. But i'm wondering what the cause is. Babies who are taking antibiotics (or whose breastfeeding moms are taking them) are more prone to this type of diaper rash because the medications kill good bacteria that keep yeast from growing. Ibuprofen can absolutely cause diaper rash in infants who are very sensitive to it! Just because its not common doesn't mean it doesn't happen. Make sure she is totally dry down there before you put a diaper on her (moisture just breeds bacteria and makes it harder for her to heal). If you can keep her out of a diaper for a little bit a few times a day, it really does help (we had this issue last week). Diaper rash appears on the skin under a diaper. Diaper rash typically occurs in infants and children younger than 2 years, but the rash can also be seen in people who are incontinent or paralyzed. Summary. Diaper rash is found among people who take Ibuprofen, especially for people who are female, 60+ old also take medication Tecfidera, and have Multiple sclerosis. Along with its needed effects, ibuprofen (the active ingredient contained in Children's Motrin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Ibuprofen may cause a rash that has ether flat lesions or small, raised lesions on the skin, according to Drugs.com. There may be red skin lesions, and they may have a purple center.